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Nortriptyline 10 mg cap acta (60mg, 10 mg, 5 mg) for the acute treatment of depression in healthy subjects. The maximum dose of medication was determined from a previous pharmacokinetic study in healthy subjects. The daily dosing regimen was chosen to ensure a consistent and adequate response between treatments. Patients were randomly assigned to five groups: placebo, 10 mg, 5 3–6 mg and 1–2–3 mg. The groups were balanced by sex, age and year of entry into the trial between 1995 and 1998. Patients were treated for two consecutive weeks with different regimens at week 1 in order to ensure a response, and then the groups were balanced for three weeks after the discontinuation of treatment. pharmacokinetics mirtazapine and paroxetine were investigated in 20 healthy subjects (20 males, 19 females, mean ± standard deviation; 20-29 yr old). After oral administration of 40 mg/d mirtazapine and 150 paroxetine to 20 healthy subjects for 30 d, the following were determined: maximum plasma concentration (Cmax)(%), total (Cmax tmax) (tmax) and half-life. Analysis of pharmacokinetics after administration was carried on the pharmacokinetic monitor (PhARM®® v2.1; Beckman Coulter/Vitro). A minimum of three patients per group were Viagra for sale vancouver evaluated. After each group, the mean Cmax is provided. minimum of three patients per group were evaluated and their responses compared. The results were expressed as mean±standard deviation (MSD). Analysis of pharmacokinetics was performed: tmax(%), t1(%), t2(%), t3(%), t4(%), t5(%), t6(%), time to 100%, and the area under curve. To evaluate the acute pharmacokinetic profile after discontinuation of treatment, the mean steady-state plasma concentration (Cmax) was determined. The maximum plasma concentration (Cmax tmax) was estimated as the minimum of 10% lowest plasma concentration (Cmax). Cmax was calculated on basis of standard curves obtained on duplicate samples that were analyzed before and after treatment in duplicate. The results are expressed as mean± standard deviation. The minimum of three patients per group were evaluated to see if any adverse effects might have appeared since treatment start. The following were evaluated on clinical inspection: physical and neurological examination; vital signs; patient's medical report after 1 week. Serum biochemical investigations (aspartate aminotransferase, alanine alkaline phosphatase, cholesterol, blood pressure, electrolytes) and hepatic function, which can be abnormal, were evaluated. Patients instructed to refrain from sex or exercise during and for 4 days after the evaluation session. patients were informed that the results could be published and used in any scientific publications. Results During the period from January 1995 to March 1998, 40 subjects were enrolled in the study. A total of 10 subjects withdrew, resulting in a total enrollment of 20 male subjects (mean ± SD, 19.6 1.5 yr old) and 20 female subjects (mean ± SD, 21.7 1.4 yr old). Mean age was 20.7 ± 1.4 yr and mean body mass index (BMI) was 27.9 ± 2.7 kg/m2. As a proportion of the initial enrollment, males were more numerous in the treated groups than females (20.7 (20.3–21.9) vs. 21.4 (19.6–21.8)) with respect to the initial cohort (P =0.03). There was no statistical difference between the groups in terms of sex ratio (male-to-female). The patients were informed on study during a clinical consultation session. Patients were required to not take any medication or supplements for 6 days before treatment. They were asked to avoid strenuous activities and heavy meals during that period. The patients were instructed to abstain from having any sex or with their spouse romantic partner during this period. They were asked to abstain from consuming alcohol for a period of three months before starting treatment and from consuming any other drugs, foods and food groups. They could drink one or two glasses of a moderate alcoholic beverage only on weekdays while they were not taking the medication. All patients were monitored for signs of fatigue throughout treatment. There were no significant changes in vital signs during the treatment period. Serum biochemical investigations were normal. All the laboratory values obtained at enrollment were within the normal limits of variation serum biochemical variables. Patients had no adverse events or reactions during medication use. After treatment was discontinued, most of the side effects (eg, nausea, tremor, headache, somnolence, insomnia, dizziness, blurred vision, nausea, anorexia, thirst [with no significant changes in urine flow), which were reported by the patients, disappeared]

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